Objective:
@EN Growth hormone secretory capacity of adults decrease with aging. Growth hormone secretory capacity and prevalence of grouwth hormone deficiency in Korean adults were studied.
@ES Methods:
@EN History, physical examination, and routine blood tests were performed to roule out ill patients among ordinary subjects. Anthropometry, nutritional history, serum insulin-like grouwth factor-1 (IGF-1) levels, L-dopa stimulation tests, and
urinary
growth hormone levels were measured in 309 Korean adults, ages 20~87 years.
@ES Results:
@EN The mean serum IGF-1 levels were 258.2±6.8ng/ml. The mean serum IGF-1 levels of adult males were significantly higher than those of the females. The serum IGF-1 levels decreased with aging. The prevalence of grouwth hormone deficiency
defined
by
serum IGF-1 levels (<150 ng/ml) were 0.0% in the 3rd decade, 5.5% in the 4th decade, 12.2% in the 5th decade, 10.0% in the 6th decade, 32.1% in the 7th decade, 48.1% in the 8th decade, respectively. The serum IGF-1 levels were positively
correlated
with
body fat mass. The peakserum growth hormone levels after L-dopa stimulation and urinary growth hormone levels of the younger subjects were significantly higher than those of the older subjects. There were good correlations among serum IGF-1
levels,
peak
growth hormone levels after L-dopa stimulation, and urinary growth hormone levels.
@ES Conclusion:
@EN Growth hormone secretory capacity decreased significantly with aging, and growth hormone deficiency was found in about 1/3 of subjects aged over 60 years.
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